Polycystic ovary syndrome is an incurable disease. So far, the causes of its formation are not known, and the treatment is mainly based on alleviating the symptoms. Symptomatic treatment concerns irregular menstruation, acne, hirsute, alopecia, and infertility. PCOS Treatment is undertaken, especially when a woman is trying to conceive. What treatments are used for polycystic ovaries?
Treatment:
1. Treatment of PCOS in case of irregular cycles
Amenorrhea or irregular menstrual bleeding is most often due to the lack of ovulation or late ovulation in the cycle. (infertility specialist in lahore)Lute-in-type progestin and oral contraceptive pills are usually used to restore menstrual rhythm. Blood concentrations of male sex hormones often increase during PCOS, so combined contraceptive pills, in which the gestate has low androgenic activity, are most beneficial. Compounds of this type are, for example, nor estimate and desogestrel. Combined contraceptives contain estrogenic and gestagen substances in their composition. There are various gestagens, but the estrogenic component is almost exclusively ethinyl estradiol.
Gestates show androgenic activity, similar to the action of male hormones, which is why the complexion may deteriorate in the second phase of the cycle. On the Pakistani market, there are also tablets containing an antiandrogenic compound – cyproterone acetate. Preparations containing this substance are not classified as contraceptives, although they have such an effect. The main purpose of using cyproterone acetate tablets is to lower the concentration of androgens in the blood. Contraception is a side effect.
2. Treatment of PCOS in the case of hirsute, acne, and alopecia
The pcos treatment pakistan is long-term and may even exceed half a year. The effects of therapy are not long-term, i.e. they last only for some time after the end of treatment. If PCOS causes symptoms such as persistent acne, hirsute, or alopecia, the following medications are used:
• cyproterone acetate, which has an ant-androgenic effect; after its use, acne lesions disappear the earliest , and excessive body hair much later;
• Oral contraceptives, where gestagens have low androgenic activity; their action consists in inhibiting the function of the ovaries and increasing the concentration of sex hormone binding globulin – SHBG (reduces the pool of free testosterone in the blood);
• spironolactone, which has an antiandrogenic effect; most often used in combination with oral contraceptives;
• flutamide, which has a strong antiandrogenic effect; in Pakistan used only in men;
• drugs that reduce insulin resistance.
3. Treatment of infertility resulting from PCOS
Infertility in PCOS is usually caused by ovulation. In women with PCOS, the stimulation of ovulation can cause many problems. On the one hand, stimulation of ovulation often turns out to be ineffective. Growing ovarian follicles do not burst, perhaps because of the thickened sheath. On the other hand, there is a high risk of hyperstimulation syndrome. How is infertility treated for polycystic ovaries?
• Weight loss in obese people. Losing 10% of your body weight can restore normal ovulation in up to half of women with polycystic ovary syndrome. A proper diet and increased physical activity increase the sensitivity of body tissues to insulin. A stabilized level of insulin in the blood causes the ovaries to produce fewer androgens. In addition, the lipid profile improves.
• Reducing insulin resistance. First of all, drugs used in type II diabetes are used: metformin and, to a lesser extent, rosiglitazone. Ovulation returns spontaneously after drug therapy, or it is easier to stimulate ovulation, which is more likely to result in successful fertilization. Long-term use of drugs reduces the symptoms caused by high concentrations of androgens in the blood, contributes to weight loss, and reduces the level of “bad cholesterol”.
• Inhibition of prolactin secretion. Drugs used in the treatment of hyperprolactinemia are used: bromocriptine, cabergoline, or pergolide.
• Pharmacological induction of ovulation. The first-line drug is usually clomiphene. If clomiphene does not work, gonadotropins are used: menopausal gonadotropin or recombinant follitropin. Gonadotropin therapy is quite expensive and increases the risk of hyperstimulation and multiple pregnancies. In many women with PCOS, especially those who are obese and insulin resistant, pharmacological stimulation of ovulation is more effective when drugs that reduce insulin resistance are administered concomitantly. If androgens are derived from the adrenal glands, stimulation of ovulation should be performed with concomitant administration of glucocorticoids.
• Ovarian surgeries. The basic procedures include wedge resection, laparoscopic ovarian puncture, or reduction of the thickness of the ovarian sheath. This increases the chances of ovulation. Unfortunately, the effects of the operation are only temporary, and there is also a risk of postoperative adhesions.
• In vitro fertilization.
4. Supporting the treatment of PCOS
There is a suspicion that many disorders in PCOS are related to insulin resistance, therefore, a low-carbohydrate diet may help treat polycystic ovary syndrome. Low carbohydrate content in the diet reduces insulin secretion and increases the sensitivity of tissues to this hormone. It is recommended either diets in which carbohydrates are practically entirely excluded or those in which you can eat foods with sugar content, but with a low glycemic index. (ivf cost in Pakistan)You should definitely give up sweets, sweetened drinks, white flour foods, potatoes, and beets. You should also limit the consumption of pasta and white rice. A radical diet, low in carbohydrates, should not be used during pregnancy. A diabetic diet, however, is highly recommended.
In order to reduce insulin resistance, it is also worth betting on physical exercise, even if it does not lead to weight loss. Cinnamon is also used to regulate the level of insulin in the blood. Taking one to three teaspoons of cinnamon tea with each meal is recommended. Chromium also normalizes carbohydrate metabolism. It is therefore worth taking dietary supplements containing this element.
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